Taking Addyi with certain medicines can increase the amount of Addyi in your blood, leading to clinically significant drug interactions. These interactions may cause severe low blood pressure, fainting (loss of consciousness), and sleepiness.
Before you start taking Addyi and throughout treatment, it is important to tell your doctor or pharmacist about all your medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Some commonly prescribed medications are contraindicated with Addyi and should be avoided.
Examples of commonly prescribed medications that you should avoid while taking Addyi include antibiotics, nefazodone (a medicine used to treat depression), and certain medicines* used to treat HIV-1 infection, fungal infections, hepatitis-C infections, high blood pressure, chest pain, or other heart problems.
*Only select medications used to treat these conditions are contraindicated with Addyi. Please refer to the Addyi Medication Guide for a more comprehensive list.